PentaBase has released a new PlentiPlex™ MSI panel intended for in vitro diagnosis of impaired DNA mismatch repair system (MMR). The PlentiPlex™ MSI PentaBase panel is a multiplexed MSI assays for the length analysis of the five mono-nucleotide microsatellite loci BAT-25, BAT-26, MONO-27, NR-22 and NR-24.
Microsatellites are genetic motifs consisting of short (one to six bases) nucleotide sequences repeated up to 100 times. During replication, these sequences are susceptible to errors, deletions and insertions, normally corrected by the DNA mismatch repair system. Uncorrected microsatellite errors are commonly referred to as microsatellite instability (MSI).
The PlentiPlex™ MSI PentaBase panel is CE IVD marked for evaluation of MMR status on DNA sequencer instruments.